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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| QUININE
| QUININE | NATURAL MOLECULE (link) ANTIPARASITIC | ORAL | Cmax 9.8 MICROMOLAR Tmax 2.8 HOUR F 82 PERCENT VD 312 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 11 LITER / HOUR (65 KILOGRAM) HT 11 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HEMOZOIN PDB 4WNV (HUMAN CYTOCHROME P450 2D6 QUININE COMPLEX) LIGAND CODE = QI9 (link to the list of PDB complexes) Download experimental 3D coordinates of QI9 with added hydrogens | FERRIPROTOPORPHYRIN IX INHIBITOR CHEMBL613897 FERRIPROTOPORPHYRIN IX PLASMODIUM FALCIPARUM | EMA | |||
