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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EMTRICITABINE
| EMTRICITABINE |
ANTIINFECTIVES | ORAL | Cmax 7.28 MICROMOLAR Tmax 1.5 HOUR F 75 PERCENT VD 261 LITER (EQN) PPB 4 PERCENT Cl 18.1 LITER / HOUR HT 10 HOUR SOLUBILITY 112 MILLIGRAM / MILLILITER IN WATER | HIV-1 REVERSE TRANSCRIPTASE PDB 2NO6 (C4S DCK VARIANT OF DCK IN COMPLEX WITH FTC+ADP) LIGAND CODE = ETV (link to the list of PDB complexes) Download experimental 3D coordinates of ETV with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE INHIBITOR CHEMBL247 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE Q72547 REVERSE TRANSCRIPTASE/RNASEH HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME HYDROLASE | EMA | |||
