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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EPLERENONE
| EPLERENONE | CARDIOVASCULAR | ORAL | Tmax 1.5 HOUR F 69 PERCENT VD 66.5 LITER PPB 50 PERCENT Cl 10 LITER / HOUR HT 5 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | MINERALOCORTICOID RECEPTOR PDB 5MWY (THE STRUCTURE OF MR IN COMPLEX WITH EPLERENONE.) LIGAND CODE = YNU (link to the list of PDB complexes) Download experimental 3D coordinates of YNU with added hydrogens | MINERALOCORTICOID RECEPTOR ANTAGONIST CHEMBL1994 MINERALOCORTICOID RECEPTOR P08235 MINERALOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C2 | EMA | |||
