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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BIMATOPROST
| BIMATOPROST | SENSORY | OPHTHALMIC TOPICAL | Cmax 0.19 NANOMOLAR Tmax 0.16 HOUR VD 43.5 LITER (65 KILOGRAM) PPB 12 PERCENT Cl 97.5 LITER / HOUR (65 KILOGRAM) HT 0.75 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | PDB 2F38 (CRYSTAL STRUCTURE OF PROSTAGLANDIN F SYNATHASE CONTAINING BIMATOPROST) LIGAND CODE = 15M (link to the list of PDB complexes) Download experimental 3D coordinates of 15M with added hydrogens | PROSTANOID FP RECEPTOR AGONIST CHEMBL1987 PROSTANOID FP RECEPTOR P43088 PROSTAGLANDIN F2-ALPHA RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR PROSTANOID RECEPTOR | EMA | |||
