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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NITISINONE
| NITISINONE | METABOLISM | ORAL | Tmax 3 HOUR F 90 PERCENT Cl 0.26 LITER / HOUR (65 KILOGRAM) HT 54 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE INHIBITOR CHEMBL1861 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE P32754 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
