SIROLIMUS (is an active metabolite) | SIROLIMUS | NATURAL MOLECULE (link) ATC L04AA10 ATC S01XA23
ANTINEOPLASTIC IMMUNOSUPPRESSIVE SIROLIMUS BINDS TO THE IMMUNOPHILIN FK BINDING PROTEIN-12 (FKBP-12) PROTEIN-PROTEIN INHIBITOR | ORAL INTRAVENOUS TOPICAL | Cmax 15.7 NANOMOLAR Tmax 2.1 HOUR F 14 PERCENT VD 780 LITER (65 KILOGRAM) PPB 92 PERCENT Cl 11.2 LITER / HOUR (65 KILOGRAM) HT 62 HOUR SOLUBILITY INSOLUBLE IN WATER | FK BINDING PROTEIN-12 (FKBP-12) PDB 5HKG (TOTAL CHEMICAL SYNTHESIS, REFOLDING AND CRYSTALLOGRAPHIC STRUCTURE OF A FULLY ACTIVE IMMUNOPHILIN: CALSTABIN 2 (FKBP12.6).) LIGAND CODE = RAP (link to the list of PDB complexes) Download experimental 3D coordinates of RAP with added hydrogens | FK506-BINDING PROTEIN 1A INHIBITOR CHEMBL1902 FK506-BINDING PROTEIN 1A P62942 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A HOMO SAPIENS ENZYME ISOMERASE | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |