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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CELECOXIB
| CELECOXIB |
MUSCULO-SKELETAL SYSTEM | ORAL | Cmax 1.85 MICROMOLAR Tmax 3 HOUR VD 429 LITER PPB 97 PERCENT Cl 27.7 LITER / HOUR HT 11.2 HOUR | PROSTAGLANDIN G/H SYNTHASE 2 PDB 3KK6 (CRYSTAL STRUCTURE OF CYCLOOXYGENASE-1 IN COMPLEX WITH CELECOXIB) LIGAND CODE = CEL (link to the list of PDB complexes) Download experimental 3D coordinates of CEL with added hydrogens | CYCLOOXYGENASE-2 INHIBITOR CHEMBL230 CYCLOOXYGENASE-2 P35354 PROSTAGLANDIN G/H SYNTHASE 2 HOMO SAPIENS ENZYME REDUCTASE | EMA | |||
