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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RABEPRAZOLE

RABEPRAZOLE


ATC A02BC04
ATC A02BC54
ATC A02BD12
ATC A02BD13

METABOLISM
ANTIULCERATIVE
ANTISECRETORY (GASTRIC ACID)
PROTON-PUMP INHIBITOR (PPI)
H+, K+ ATPASE INHIBITOR

ORAL

Cmax 1.84 MICROMOLAR (PMID18621671)

Tmax 3.5 HOUR

F 52 PERCENT

VD 14.3 LITER (65 KILOGRAM)

PPB 96.3 PERCENT

Cl 15.6 LITER / HOUR (65 KILOGRAM)

HT 1.5 HOUR

SOLUBILITY VERY SOLUBLE IN WATER

POTASSIUM-TRANSPORTING ATPASE

PDB 3PGL (CRYSTAL STRUCTURE OF HUMAN SMALL C-TERMINAL DOMAIN PHOSPHATASE 1 (SCP1) BOUND TO RABEPRAZOLE)

LIGAND CODE = RZX (link to the list of PDB complexes)

Download experimental 3D coordinates of RZX with added hydrogens

POTASSIUM-TRANSPORTING ATPASE INHIBITOR CHEMBL2095173 POTASSIUM-TRANSPORTING ATPASE P20648 POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1 HOMO SAPIENS ENZYME HYDROLASEEMA

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