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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TOLCAPONE
| TOLCAPONE | NERVOUS SYSTEM | ORAL | Cmax 21.9 MICROMOLAR Tmax 2 HOUR F 65 PERCENT VD 9 LITER PPB 99.9 PERCENT Cl 7 LITER / HOUR HT 2.5 HOUR | CATECHOL O-METHYLTRANSFERASE PDB 5A6I (V122I TRANSTHYRETIN STRUCTURE IN COMPLEX WITH TOLCALPONE) LIGAND CODE = TCW (link to the list of PDB complexes) Download experimental 3D coordinates of TCW with added hydrogens | CATECHOL O-METHYLTRANSFERASE INHIBITOR CHEMBL2023 CATECHOL O-METHYLTRANSFERASE P21964 CATECHOL O-METHYLTRANSFERASE HOMO SAPIENS ENZYME TRANSFERASE | EMA | |||
