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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NEVIRAPINE
| NEVIRAPINE |
ANTIINFECTIVES | ORAL | Cmax 16.9 MICROMOLAR F 93 PERCENT VD 78.6 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 1.17 LITER / HOUR (65 KILOGRAM) HT 45 HOUR | HIV REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN) PDB 1JLF (CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE) LIGAND CODE = NVP (link to the list of PDB complexes) Download experimental 3D coordinates of NVP with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE INHIBITOR CHEMBL247 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE Q72547 REVERSE TRANSCRIPTASE/RNASEH HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME HYDROLASE | EMA | |||
