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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEVOFLOXACIN
| LEVOFLOXACIN OFLOXACIN |
ANTIINFECTIVES | ORAL INJECTION OPHTHALMIC OTIC | Cmax 33.5 MICROMOLAR Tmax 1.4 HOUR F 99 PERCENT VD 80 LITER PPB 31 PERCENT Cl 7.5 LITER / HOUR HT 7.9 HOUR SOLUBILITY OF 50 MILLIGRAM / MILLILITER IN WATER | DNA TOPOISOMERASE IV DNA GYRASE PDB 5EIX (QUINOLONE-STABILIZED CLEAVAGE COMPLEX OF TOPOISOMERASE IV FROM KLEBSIELLA PNEUMONIAE) LIGAND CODE = LFX (link to the list of PDB complexes) Download experimental 3D coordinates of LFX with added hydrogens | DNA GYRASE INHIBITOR CHEMBL2311225 DNA GYRASE P0A4L9 DNA GYRASE SUBUNIT B STREPTOCOCCUS PNEUMONIAE ENZYME ISOMERASE | EMA | |||
