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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GEMFIBROZIL
| GEMFIBROZIL | CARDIOVASCULAR | ORAL | Cmax 184 MICROMOLAR Tmax 1.5 HOUR F 100 PERCENT VD 11 LITER PPB 98 PERCENT Cl 7.8 LITER / HOUR HT 1.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (IN ACID IS 0.0019 PERCENT) | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA PDB 5BOJ (CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH GEMFIBROZIL) LIGAND CODE = 4TX (link to the list of PDB complexes) Download experimental 3D coordinates of 4TX with added hydrogens | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA AGONIST CHEMBL239 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA Q07869 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1C NR1C1 | EMA | |||
