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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BROMOCRIPTINE
| BROMOCRIPTINE | NERVOUS SYSTEM | ORAL | Cmax 711 PICOMOLAR Tmax 2.5 HOUR F 80 PERCENT VD 61 LITER PPB 93 PERCENT Cl 7 LITER / HOUR (EQN) HT 6 HOUR | D(2) DOPAMINE RECEPTOR PDB 5VCG (CRYSTAL STRUCTURE OF THE CYSTEINE DEPLETED CYP3A4 BOUND TO BROMOERGOCRYPTINE) LIGAND CODE = 08Y (link to the list of PDB complexes) Download experimental 3D coordinates of 08Y with added hydrogens | 5-HYDROXYTRYPTAMINE RECEPTOR 1A P08908 5-HYDROXYTRYPTAMINE RECEPTOR 1A HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR SEROTONIN RECEPTOR | EMA | |||
