METYRAPONE | METYRAPONE | ATC V04CD01
VARIOUS ANTIMETABOLITES INHIBITOR OF ENDOGENOUS ADRENAL CORTICOSTEROID SYNTHESIS REDUCE CORTISOL AND CORTICOSTERONE PRODUCTION BY INHIBITING THE 11-BETA-HYDROXYLATION REACTION IN THE ADRENAL CORTEX RESULTING IN AN INCREASE IN ADRENOCORTICOTROPIC HORMONE (ACTH) PRODUCTION BY THE PITUITARY ALSO SUPPRESS BIOSYNTHESIS OF ALDOSTERONE CYP11B1 INHIBITOR | ORAL | Cmax 32.3 MICROMOLAR Tmax 1 HOUR HT 1.9 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | CYTOCHROME P450 CYP11B1 PDB 1W0G (CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4) LIGAND CODE = MYT (link to the list of PDB complexes) Download experimental 3D coordinates of MYT with added hydrogens | ENZYME C11B1_HUMAN INHIBITOR P15538 | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |