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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DEFACTINIB
| DEFACTINIB | ANTINEOPLASTIC | ORAL | Tmax 4 HOUR VD 1560 LITER PPB 90 PERCENT Cl 69 LITER / HOUR HT 9 HOUR SOLUBILITY INSOLUBLE IN WATER | FAK PYK2 PDB 5MAH (CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR) LIGAND CODE = 7KD (link to the list of PDB complexes) Download experimental 3D coordinates of 7KD with added hydrogens | - more at DrugCentral | EMA | |||
