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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LAZERTINIB
| LAZERTINIB | ANTINEOPLASTIC | ORAL | Tmax 3 HOUR VD 2680 LITER PPB 99.2 PERCENT Cl 36.4 LITER / HOUR HT 88.8 HOUR | EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PDB 7UKV (WILD TYPE EGFR IN COMPLEX WITH LAZERTINIB (YH25448)) LIGAND CODE = ZRT (link to the list of PDB complexes) Download experimental 3D coordinates of ZRT with added hydrogens | - more at DrugCentral | EMA | |||
