DARIDOREXANT | DARIDOREXANT | NERVOUS SYSTEM OREXIN RECEPTOR ANTAGONIST TREATMENT OF INSOMNIA OREXIN-1 RECEPTOR (KI=0.47 NANOMOLAR) OREXIN-2 RECEPTOR (KI=0.93 NANOMOLAR) | ORAL | Tmax 1.5 HOUR F 62 PERCENT VD 31 LITER PPB 99.7 PERCENT HT 8 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | OREXIN-1 RECEPTOR (OX1R) OREXIN-2 RECEPTOR (OX2R) PDB 6TP3 (CRYSTAL STRUCTURE OF THE OREXIN-1 RECEPTOR IN COMPLEX WITH DARIDOREXANT) LIGAND CODE = NS2 (link to the list of PDB complexes) Download experimental 3D coordinates of NS2 with added hydrogens | More at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |