AVACOPAN | AVACOPAN | ATC L04AA59
CARDIOVASCULAR COMPLEMENT 5A RECEPTOR (C5AR) ANTAGONIST TREATMENT OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIS BLOCKS C5A-INDUCED UPREGULATION OF CD11B ON NEUTROPHILS | ORAL | Cmax 600 NANOMOLAR Tmax 2 HOUR VD 345 LITER PPB 99.9 PERCENT Cl 16.3 LITER / HOUR HT 97.6 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | C5AR PDB 6C1R (CRYSTAL STRUCTURE OF HUMAN C5A RECEPTOR IN COMPLEX WITH AN ORTHOSTERIC ANTAGONIST PMX53 AND AN ALLOSTERIC ANTAGONIST AVACOPAN) LIGAND CODE = EFD (link to the list of PDB complexes) Download experimental 3D coordinates of EFD with added hydrogens | More at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |