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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SN38

SN38
SACITUZUMAB GOVITECAN-HZIY

ANTINEOPLASTIC
ANTIBODY-DRUG CONJUGATE (ADC)
A TOPOISOMERASE INHIBITOR
TREATMENT OF METASTATIC TRIPLE-NEGATIVE BREAST CANCER (MTNBC)

INJECTION

Cmax 323.6 NANOMOLAR

HT 18 HOUR

TOPOISOMERASE

PDB 6VXJ (STRUCTURE OF ABCG2 BOUND TO SN38)

LIGAND CODE = RS4 (link to the list of PDB complexes)

Download experimental 3D coordinates of RS4 with added hydrogens

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