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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CHLORAMBUCIL
| CHLORAMBUCIL | ANTINEOPLASTIC | ORAL | Cmax 1.6 MICROMOLAR Tmax 0.83 HOUR VD 20.15 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 10.9 LITER / HOUR (65 KILOGRAM) HT 1.3 HOUR | DNA PDB 3CSJ (HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH CHLORAMBUCIL) LIGAND CODE = CBL (link to the list of PDB complexes) Download experimental 3D coordinates of CBL with added hydrogens | DNA INHIBITOR CHEMBL2311221 DNA HOMO SAPIENS | EMA | |||
