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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OSILODROSTAT
| OSILODROSTAT | HORMONES | ORAL | Tmax 1 HOUR VD 100 LITER PPB 36.4 PERCENT HT 4 HOUR | 11 BETA-HYDROXYLASE (CYP11B1) PDB 7M8V (HUMAN CYP11B2 IN COMPLEX WITH LCI699) LIGAND CODE = YSY (link to the list of PDB complexes) Download experimental 3D coordinates of YSY with added hydrogens | Cytochrome P450 11B1, mitochondrial inhibitor P15538 (C11B1_HUMAN) | EMA | |||
