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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEMBOREXANT
| LEMBOREXANT | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR VD 1970 LITER PPB 94 PERCENT HT 19 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | OREXIN-1 RECEPTOR (IC50=6.1 NM) OREXIN-2 RECEPTOR (IC50=2.6 NM) PDB 6TOT (CRYSTAL STRUCTURE OF THE OREXIN-1 RECEPTOR IN COMPLEX WITH LEMBOREXANT) LIGAND CODE = NRK (link to the list of PDB complexes) Download experimental 3D coordinates of NRK with added hydrogens | Orexin receptor type 1 antagonist O43613 OX1R_HUMAN | EMA | |||
