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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALPELISIB
| ALPELISIB | ANTINEOPLASTIC | ORAL | Cmax 5.6 MICROMOLAR Tmax 3 HOUR VD 114 LITER PPB 89 PERCENT Cl 9.2 LITER / HOUR HT 8.5 HOUR | PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) PDB 4JPS (CO-CRYSTAL STRUCTURES OF THE LIPID KINASE PI3K ALPHA WITH PAN AND ISOFORM SELECTIVE INHIBITORS) LIGAND CODE = 1LT (link to the list of PDB complexes) Download experimental 3D coordinates of 1LT with added hydrogens | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform P42336 | EMA | |||
