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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TAFAMIDIS
| TAFAMIDIS | CARDIOVASCULAR | ORAL | Tmax 4 HOUR VD 18.5 LITER PPB 99 PERCENT Cl 0.263 LITER / HOUR HT 49 HOUR | TRANSTHYRETIN PDB 3TCT (STRUCTURE OF WILD-TYPE TTR) LIGAND CODE = 3MI (link to the list of PDB complexes) Download experimental 3D coordinates of 3MI with added hydrogens | Transthyretin TTHY_HUMAN P02766 | EMA | |||
