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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M APALUTAMIDE (is an active metabolite)

APALUTAMIDE


ATC L02BB05

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR INDICATED FOR THE TREATMENT OF PATIENTS WITH NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
N-DESMETHYL APALUTAMIDE, IS A LESS POTENT INHIBITOR OF AR, AND EXHIBITED ONE-THIRD THE ACTIVITY

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Cmax 12.7 MICROMOLAR

PPB 95 PERCENT

ANDROGEN RECEPTOR

NUCLEAR RECEPTOR ANDR_HUMAN INHIBITOR P10275EMA

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