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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LOFEXIDINE
| LOFEXIDINE | NERVOUS SYSTEM | ORAL | Cmax 3.16 NANOMOLAR Tmax 4 HOUR F 72 PERCENT (0.36 MILLIGRAM) VD 480 LITER PPB 55 PERCENT Cl 17.6 LITER / HOUR HT 12 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | ALPHA-2 ADRENERGIC RECEPTOR | GPCR ADA2A_HUMAN AGONIST P08913 | EMA | |||
