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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRASTERONE (has an active metabolite)
| PRASTERONE |
HORMONES | VAGINAL | Cmax 15 NANOMOLAR SOLUBILITY INSOLUBLE IN WATER | HYDROXYSTEROID DEHYDROGENASES 5ALPHA-REDUCTASES AROMATASES PDB 1Q22 (CRYSTAL STRUCTURE OF HUMAN CHOLESTEROL SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OF DHEA AND PAP) LIGAND CODE = AND (link to the list of PDB complexes) Download experimental 3D coordinates of AND with added hydrogens | Sex hormone-binding globulin P04278 (SHBG_HUMAN) | EMA | |||
