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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IDELALISIB
| IDELALISIB | ANTINEOPLASTIC | ORAL | Tmax 1.5 HOUR VD 23 LITER PPB 84 PERCENT Cl 14.9 LITER / HOUR HT 8.2 HOUR SOLUBILITY PH-DEPENDENT AQUEOUS SOLUBILITY 0.1 MILLIGRAM / MILLILITER (PH 5-7) | PHOSPHOINOSITIDE 3-KINASE DELTA PDB 4XE0 (IDELALISIB BOUND TO THE P110 SUBUNIT OF PI3K DELTA) LIGAND CODE = 40L (link to the list of PDB complexes) Download experimental 3D coordinates of 40L with added hydrogens | PI3-KINASE P110-DELTA SUBUNIT INHIBITOR CHEMBL3130 PI3-KINASE P110-DELTA SUBUNIT O00329 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM HOMO SAPIENS ENZYME | EMA | |||
