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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BEDAQUILINE
| BEDAQUILINE | ANTIINFECTIVES | ORAL | VD 164 LITER PPB 99.9 PERCENT Cl 0.03 LITER / HOUR (EQN) HT 3960 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA | ATP (ADENOSINE 5PRIME-TRIPHOSPHATE) SYNTHASE PDB 4V1F (CRYSTAL STRUCTURE OF A MYCOBACTERIAL ATP SYNTHASE ROTOR RING IN COMPLEX WITH BEDAQUILINE) LIGAND CODE = BQ1 (link to the list of PDB complexes) Download experimental 3D coordinates of BQ1 with added hydrogens | ATP SYNTHASE INHIBITOR CHEMBL2364166 ATP SYNTHASE P9WPS1 ATP SYNTHASE SUBUNIT C MYCOBACTERIUM TUBERCULOSIS ENZYME HYDROLASE | EMA | |||
