| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| APIXABAN
| APIXABAN | BLOOD | ORAL | Tmax 3.5 HOUR F 50 PERCENT VD 21 LITER PPB 87 PERCENT Cl 3.3 LITER / HOUR HT 12 HOUR SOLUBILITY AQUEOUS SOLUBILITY ACROSS THE PHYSIOLOGICAL PH RANGE IS 0.04 MILLIGRAM / MILLILITER | FACTOR XA PDB 2P16 (FACTOR XA IN COMPLEX WITH THE INHIBITOR APIXABAN (BMS-562247) AKA 1-(4-METHOXYPHENYL)-7-OXO-6-(4-(2-OXO-1-PIPERIDINYL)PHENYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3, 4-C]PYRIDINE-3-CARBOXAMIDE) LIGAND CODE = GG2 (link to the list of PDB complexes) Download experimental 3D coordinates of GG2 with added hydrogens | COAGULATION FACTOR X INHIBITOR CHEMBL244 COAGULATION FACTOR X P00742 COAGULATION FACTOR X HOMO SAPIENS ENZYME PROTEASE SERINE PAS S1A | EMA | |||
