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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CABAZITAXEL
| CABAZITAXEL | ANTINEOPLASTIC | INTRAVENOUS INJECTION | Cmax 270 NANOMOLAR (25 MILLIGRAM / M2) VD 4864 LITER PPB 91 PERCENT Cl 48.5 LITER / HOUR HT 95 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | MICROTUBULE BINDS TO TUBULIN AND PROMOTES ITS ASSEMBLY INTO MICROTUBULES WHILE SIMULTANEOUSLY INHIBITING DISASSEMBLY | TUBULIN INHIBITOR CHEMBL2095182 TUBULIN P04350 TUBULIN BETA-4A CHAIN HOMO SAPIENS STRUCTURAL | EMA | |||
