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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PROGESTERONE
| PROGESTERONE | GENITO | INJECTION INTRAUTERINE ORAL VAGINAL | Cmax 193 NANOMOLAR Tmax 1.7 HOUR VD 5252 LITER (EQN) PPB 97 PERCENT Cl 104.6 LITER / HOUR HT 34.8 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PROGESTERONE RECEPTOR PDB 4L1W (CRYSTAL STRUCTUER OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+ AND PROGESTERONE) LIGAND CODE = STR (link to the list of PDB complexes) Download experimental 3D coordinates of STR with added hydrogens | PROGESTERONE RECEPTOR AGONIST CHEMBL208 PROGESTERONE RECEPTOR P06401 PROGESTERONE RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C3 | EMA | |||
