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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FLUTICASONE FUROATE
| FLUTICASONE FUROATE |
RESPIRATORY | NASAL INHALATION | Cmax NOT QUANTIFIABLE (ROUTE = INTRANASAL) F 1.26 PERCENT VD 608 LITER PPB 99 PERCENT Cl 58.7 LITER / HOUR HT 15.1 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HUMAN GLUCOCORTICOID RECEPTOR PDB 3CLD (LIGAND BINDING DOMAIN OF THE GLUCOCORTICOID RECEPTOR COMPLEXED WITH FLUTICAZONE FUROATE) LIGAND CODE = GW6 (link to the list of PDB complexes) Download experimental 3D coordinates of GW6 with added hydrogens | GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1 | EMA | |||
