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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIOPRONIN
| TIOPRONIN | RESPIRATORY | ORAL | Cmax 61.9 MICROMOLAR Tmax 3 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PDB 5A5Z (APPROVED DRUGS CONTAINING THIOLS AS INHIBITORS OF METALLO-BETA- LACTAMASES: STRATEGY TO COMBAT MULTIDRUG-RESISTANT BACTERIA) LIGAND CODE = WJZ (link to the list of PDB complexes) Download experimental 3D coordinates of WJZ with added hydrogens | REDUCING AGENT | EMA | |||
