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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SITAGLIPTIN
| SITAGLIPTIN |
METABOLISM | ORAL | Cmax 950 NANOMOLAR (100 MILLIGRAM) F 87 PERCENT VD 198 LITER PPB 38 PERCENT Cl 11 LITER / HOUR (EQN) HT 12.4 HOUR SOLUBILITY SOLUBLE IN WATER | DIPEPTIDYL PEPTIDASE 4 (DPP-4) PDB 4FFW (CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPP4, DPP-IV, CD26) IN COMPLEX WITH FAB + SITAGLIPTIN) LIGAND CODE = 715 (link to the list of PDB complexes) Download experimental 3D coordinates of 715 with added hydrogens | DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9B | EMA | |||
