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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DARUNAVIR
| DARUNAVIR |
ANTIINFECTIVES | ORAL | F 59 PERCENT VD 417 LITER (EQN) PPB 95 PERCENT Cl 19.3 LITER / HOUR HT 15 HOUR SOLUBILITY 0.15 MILLIGRAM / MILLILITER IN WATER | HIV-1 PROTEASE PDB 4Q1W (MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE) LIGAND CODE = 017 (link to the list of PDB complexes) Download experimental 3D coordinates of 017 with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE INHIBITOR CHEMBL243 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE Q72874 POL POLYPROTEIN HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME PROTEASE ASPARTIC AA A2A | EMA | |||
