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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SAQUINAVIR DISCONTINUED
| SAQUINAVIR | ANTIINFECTIVES | ORAL | F 4 PERCENT VD 700 LITER (12 MILLIGRAM) PPB 98 PERCENT Cl 74.1 LITER / HOUR (65 KILOGRAM) HT 7 HOUR SOLUBILITY 2.22 MILLIGRAM PER MILLILITER | HIV-1 PROTEASE (IC50= 37 NANOMOLAR) PDB 3D1Y (CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR SAQUINA) LIGAND CODE = ROC (link to the list of PDB complexes) Download experimental 3D coordinates of ROC with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE INHIBITOR CHEMBL243 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE Q72874 POL POLYPROTEIN HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME PROTEASE ASPARTIC AA A2A | EMA | |||
