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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MAFENIDE
| MAFENIDE | DERMATOLOGICALS | TOPICAL | Cmax 1.06 MILLIMOLAR (77 GRAM) Tmax 2 HOUR SOLUBILITY SOLUBLE IN WATER | CARBONIC ANHYDRASE (SECONDARY ) PDB 5JNC (CRYSTAL STRUCTURE FOR THE COMPLEX OF HUMAN CARBONIC ANHYDRASE IV AND 4-AMINOMETHYLBENZENE SULFONAMIDE) LIGAND CODE = 6LH (link to the list of PDB complexes) Download experimental 3D coordinates of 6LH with added hydrogens | BACTERIAL DIHYDROPTEROATE SYNTHASE INHIBITOR CHEMBL2364668 BACTERIAL DIHYDROPTEROATE SYNTHASE P0AC13 DIHYDROPTEROATE SYNTHASE BACTERIA ENZYME TRANSFERASE | EMA | |||
