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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIMANTADINE
| RIMANTADINE | ANTIINFECTIVES | ORAL | Cmax 510 NANOMOLAR VD 219 LITER (EQN) PPB 40 PERCENT Cl 3.9 LITER / HOUR HT 39 HOUR SOLUBILITY SOLUBLE IN WATER (50 MILLIGRAM / MILLILITER) | PROTON TRANSPORTER M2 (PMID23480101) PDB 2BOC (INFLUENZA A M2 TRANSMEMBRANE DOMAIN BOUND TO RIMANTADINE IN THE INWARD(OPEN) CONFORMATION) LIGAND CODE = EU7 (link to the list of PDB complexes) Download experimental 3D coordinates of EU7 with added hydrogens | INFLUENZA VIRUS A MATRIX PROTEIN M2 INHIBITOR CHEMBL2052 INFLUENZA VIRUS A MATRIX PROTEIN M2 P63231 MATRIX PROTEIN 2 INFLUENZA A VIRUS (A/UDORN/307/1972(H3N2)) ION CHANNEL OTHER MISC M2-C | EMA | |||
