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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LINCOMYCIN
| LINCOMYCIN | NATURAL MOLECULE (link) ANTIINFECTIVES | ORAL INJECTION | Cmax 39 MICROMOLAR (600 MILLIGRAM) VD 65 LITER (65 KILOGRAM) PPB 57 PERCENT Cl 8.2 LITER / HOUR (65 KILOGRAM) HT 5.4 HOUR SOLUBILITY IS FREELY SOLUBLE IN WATER | 50S RIBOSOMAL PROTEIN PDB 5HKV (THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINCOMYCIN) LIGAND CODE = 3QB (link to the list of PDB complexes) Download experimental 3D coordinates of 3QB with added hydrogens | 70S RIBOSOME INHIBITOR CHEMBL2363853 70S RIBOSOME 23S RIBOSOMAL RNA STREPTOCOCCUS PNEUMONIAE | EMA | |||
