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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VARENICLINE
| VARENICLINE | NERVOUS SYSTEM | ORAL NASAL | Tmax 3.5 HOUR F 90 PERCENT VD 415 LITER PPB 20 PERCENT HT 24 HOUR SOLUBILITY HIGHLY SOLUBLE IN WATER | NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 BETA-2 5-HT3 RECEPTOR (KI=350 NANOMOLAR) PDB 5AIN (VARENICLINE INTERACTIONS AT THE 5HT3 RECEPTOR LIGAND BINDING SITE ARE REVEALED BY 5HTBP) LIGAND CODE = QMR (link to the list of PDB complexes) Download experimental 3D coordinates of QMR with added hydrogens | NEURONAL ACETYLCHOLINE RECEPTOR ALPHA4/BETA2 AGONIST CHEMBL1907589 NEURONAL ACETYLCHOLINE RECEPTOR ALPHA4/BETA2 P17787 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 HOMO SAPIENS ION CHANNEL LGIC ACH CHRN BETA | EMA | |||
