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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIPRANAVIR
| TIPRANAVIR | ANTIINFECTIVES | ORAL | Cmax 94.8 MICROMOLAR (500 MILLIGRAM) Tmax 2.9 HOUR VD 8.5 LITER PPB 99.9 PERCENT Cl 1.15 LITER / HOUR HT 5.5 HOUR SOLUBILITY INSOLUBLE IN WATER | HIV-1 PROTEASE PDB 3SPK (TIPRANAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT) LIGAND CODE = TPV (link to the list of PDB complexes) Download experimental 3D coordinates of TPV with added hydrogens | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE INHIBITOR CHEMBL243 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE Q72874 POL POLYPROTEIN HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME PROTEASE ASPARTIC AA A2A | EMA | |||
