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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ERLOTINIB
| ERLOTINIB | ANTINEOPLASTIC | ORAL | F 100 PERCENT VD 232 LITER PPB 93 PERCENT Cl 4.4 LITER / HOUR (EQN) HT 36.2 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PDB 4HJO (CRYSTAL STRUCTURE OF THE INACTIVE EGFR TYROSINE KINASE DOMAIN WITH ERLOTINIB) LIGAND CODE = AQ4 (link to the list of PDB complexes) Download experimental 3D coordinates of AQ4 with added hydrogens | EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 INHIBITOR CHEMBL203 EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 P00533 EPIDERMAL GROWTH FACTOR RECEPTOR HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK EGFR | EMA | |||
