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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CLOFARABINE (has an active metabolite)
| CLOFARABINE | ANTINEOPLASTIC | INTRAVENOUS INJECTION | VD 276 LITER PPB 47 PERCENT Cl 46 LITER / HOUR HT 5.2 HOUR | DEOXYCYTIDINE KINASE PDB 2A7Q (CRYSTAL STRUCTURE OF HUMAN DCK COMPLEXED WITH CLOFARABINE AND ADP) LIGAND CODE = CFB (link to the list of PDB complexes) Download experimental 3D coordinates of CFB with added hydrogens | DNA INHIBITOR CHEMBL2311221 DNA P09884 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT HOMO SAPIENS ENZYME TRANSFERASE | EMA | |||
