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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PALONOSETRON
| PALONOSETRON | METABOLISM | INTRAVENOUS ORAL INJECTION | Cmax 18.9 NANOMOLAR Tmax 5.1 HOUR F 97 PERCENT VD 539.5 LITER (65 KILOGRAM) PPB 62 PERCENT Cl 10.4 LITER / HOUR (65 KILOGRAM) HT 40 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | 5-HYDROXYTRYPTAMINE 3 RECEPTOR PDB 6Y1Z (MOUSE SEROTONIN 5HT3 RECEPTOR IN COMPLEX WITH PALONOSETRON) LIGAND CODE = O7B (link to the list of PDB complexes) Download experimental 3D coordinates of O7B with added hydrogens | SEROTONIN 3A (5-HT3A) RECEPTOR ANTAGONIST CHEMBL1899 SEROTONIN 3A (5-HT3A) RECEPTOR P46098 5-HYDROXYTRYPTAMINE RECEPTOR 3A HOMO SAPIENS ION CHANNEL LGIC 5HT3 | EMA | |||
