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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PIOGLITAZONE
| PIOGLITAZONE |
METABOLISM | ORAL | Tmax 2 HOUR VD 41 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 6 LITER / HOUR HT 5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA PDB 5Y2O (STRUCTURE OF PPARGAMMA LIGAND BINDING DOMAIN-PIOGLITAZONE COMPLEX) LIGAND CODE = 8N6 (link to the list of PDB complexes) Download experimental 3D coordinates of 8N6 with added hydrogens | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONIST CHEMBL235 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA P37231 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1C NR1C3 | EMA | |||
