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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MONTELUKAST
| MONTELUKAST | RESPIRATORY SYSTEM | ORAL | Tmax 3.5 HOUR F 64 PERCENT VD 9.5 LITER PPB 99 PERCENT Cl 2.7 LITER / HOUR HT 4.1 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLT1) PDB 2NNI (CYP2C8DH COMPLEXED WITH MONTELUKAST) LIGAND CODE = MTK (link to the list of PDB complexes) Download experimental 3D coordinates of MTK with added hydrogens | CYSTEINYL LEUKOTRIENE RECEPTOR 1 ANTAGONIST CHEMBL1798 CYSTEINYL LEUKOTRIENE RECEPTOR 1 Q9Y271 CYSTEINYL LEUKOTRIENE RECEPTOR 1 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR LEUKOTRIENE RECEPTOR | EMA | |||
