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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ZONISAMIDE
| ZONISAMIDE | NERVOUS SYSTEM | ORAL | Tmax 4 HOUR VD 94 LITER (65 KILOGRAM) PPB 40 PERCENT Cl 1.17 LITER / HOUR (65 KILOGRAM) HT 63 HOUR SOLUBILITY MODERATELY SOLUBLE IN WATER | SODIUM CHANNEL VOLTAGE-DEPENDENT CALCIUM CHANNEL GABA/BENZODIAZEPINE RECEPTOR IONOPHORE COMPLEX CARBONIC ANHYDRASE PDB 3PO7 (HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ZONISAMIDE) LIGAND CODE = ZON (link to the list of PDB complexes) Download experimental 3D coordinates of ZON with added hydrogens | SODIUM CHANNEL ALPHA SUBUNIT BLOCKER CHEMBL2331043 SODIUM CHANNEL ALPHA SUBUNIT P35498 SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA HOMO SAPIENS ION CHANNEL VGC VG NA | EMA | |||
