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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LETROZOLE
| LETROZOLE | ANTINEOPLASTIC | ORAL | VD 123.5 LITER (65 KILOGRAM) PPB 39 PERCENT Cl 2.22 LITER / HOUR (65 KILOGRAM) HT 48 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CYTOCHROME P450 19 (AROMATASE) | CYTOCHROME P450 19A1 INHIBITOR CHEMBL1978 CYTOCHROME P450 19A1 P11511 AROMATASE HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_19 CYP_19A CYP_19A1 | EMA | |||
