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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IMIQUIMOD
| IMIQUIMOD | DERMATOLOGICALS | TOPICAL | Cmax 1.34 NANOMOLAR Tmax 9 HOUR HT 29.3 HOUR | TOLL-LIKE RECEPTOR 7 PDB 5LBT (STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH IMIQUIMOD) LIGAND CODE = 6T0 (link to the list of PDB complexes) Download experimental 3D coordinates of 6T0 with added hydrogens | TOLL-LIKE RECEPTOR 7 AGONIST CHEMBL5936 TOLL-LIKE RECEPTOR 7 Q9NYK1 TOLL-LIKE RECEPTOR 7 HOMO SAPIENS MEMBRANE RECEPTOR TOLL-LIKE AND IL-1 | EMA | |||
